Fertility Services
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Fertility Services

 

For Women

Hormonal testing for women is recommended based on medical or physical examination.

Clomiphene citrate challenge test:  follicle stimulating hormone (FSH) level is obtained on the third day of the menstrual cycle.  Clomiphene citrate 100 mg is then administered on cycle days 5 through 9.  A repeat FSH value is obtained on the 10th day of the menstrual cycle.  A high FSH value on either day 3 or day 10 bodes poorly for a woman’s ability to get pregnant.  Medical treatment will not improve fertility in women with an elevated FSH level.  The use of donated eggs is a treatment option.

Estradiol:  daily measurement of estradiol helps determine the response to medications which stimulate ovulation.  During ovulation induction, we use these results to determine how much treatment is necessary, and for how long.

FSH and LH:  FSH is often elevated in women whose ovaries are less likely to contain healthy eggs.  This can help us identify women who are unlikely to conceive because of poor egg quality.  Low levels of luteinizing hormone (LH) and FSH may indicate a malfunction in the pituitary gland or hypothalamus.  An elevation of LH may indicate the presence of Polycystic Ovarian Disease, which may be a cause of irregular menstrual cycles.  In these cases, hormonal treatment with ovulation induction medication often stimulates ovulation.

Insulin resistance:  an association between insulin resistance and menstrual irregularity has been identified.  It has been shown that in some cases, treating the abnormality in glucose metabolism can regulate the menstrual cycle.  In addition, insulin resistance has been associated with the development of diabetes and heart disease.  Glucose and insulin tolerance testing may be indicated to identify those women who would benefit from this treatment.

Progesterone:  progesterone is measured after ovulation has occurred to determine if the ovaries are functioning properly.  Consistently low findings indicate that the corpus luteum is not working properly.  This condition, known as a luteal phase defect, is often treated with progesterone or medication to induce ovulation.

Prolactin:  this hormone prepares the breasts to produce milk.  In non-nursing women, high levels can interfere with ovulation.  High prolactin levels can usually be treated with medication.

Thyroid Function Tests:  women with abnormal ovulation may have an over or underactive thyroid, which may be due to disease or age.  This test may be ordered in women who have no other explanation for infertility.

Testosterone and other Androgens:  women normally produce small amounts of these “male hormones” in their ovaries and adrenal glands.  Overproduction of these hormones can block ovulation.

 

For Men

Problems with sperm can reflect hormonal changes that can be treated medically.  We recommend obtaining hormone levels in men who have persistently abnormal semen analyses.  Hormonal treatment is appropriate only in men with specific hormonally-caused sperm problems.

Discussion of medical and surgical history:  This includes a history of systemic diseases, such as viral infections (particularly postpubertal mumps and venereal disease), fevers, and diabetes mellitus, previous surgery, especially in the genitourinary area, during of infertility, previous pregnancies, and sexual history.  Many men had a hernia repair as babies and this occasionally causes a blockage of the vas due to scar tissue or to just bad surgical practices.

Physical exam:  This includes an examination of testicle position in the scrotum (if the testicles haven’t descended properly, the sperm will not be cool enough), an examination of the scrotum for varicocles (varicose veins of the testicles), and an examination of the prostate and prostatic fluid for signs of infection.  Also, fat and hair distribution is examined, for signs of hormone imbalance.

Urinalysis:  Look for signs of a urinary tract infection, presence of sperm in the urine (which, in conjunction with a low sperm count, may indicate retrograde ejaculation), and signs of systemic disorders such as kidney problems or diabetes mellitus.

Follicle Stimulating Hormones (FSH) and Luteinizing Hormone (LH):  high FSH and LH occur in men with testicular failure; which is unlikely to be helped by medications and/or surgery.  Low levels of LH and FSH may indicate a malfunction in the pituitary gland or hypothalamus gland.  In these cases, hormone therapy may improve fertility.

Prolactin:  an elevation in prolactin levels can cause male infertility and decreased sexual drive.  This abnormality can often be treated with medication.

Testosterone:  testosterone is important for sex drive and performance as well as for maintaining sperm motility.

Thyroid Function Tests:  thyroid gland dysfunction is rarely a cause of male infertility.

Semen Analysis:  This is done at least three times, since sperm count varies, and a 2-3 day abstinence is required before each analysis.  Normal values follow:

   Ejaculatory volume:              1.5-5.0 cc

   Sperm Density:                     >20 million/ml

   Motility:                                   >60%

   Forward Progression:          >2, on a scale of 1-4

   Morphology:                           >60% normal forms (should have oval head & long tail)

And:    1.  no significant microscopic sperm clumping,

2.      no significant white or red blood cells,

3.      no increased thickening of the seminal fluid (hyperviscosity).

 

           

 

Art © Sandra Kuck